ABSTRACT
Spinal cord injury is a significant cause of motor dysfunctions. There is no definite cure for it, and most of the therapeutic modalities are only symptomatic treatment. In this systematic review and meta-analysis, the effectiveness of stem cell therapy in the treatment of the spinal cord injuries in animal models was studied and evaluated. A systematic search through medical databases by using appropriate keywords was conducted. The relevant reports were reviewed in order to find out cases in which inclusion and exclusion criteria had been fulfilled. Finally, 89 articles have been considered, from which 28 had sufficient data for performing statistical analyses. The findings showed a significant improvement in motor functions after cell therapy. The outcome was strongly related to the number of transplanted cells, site of injury, chronicity of the injury, type of the damage, and the induction of immune-suppression. According to our data, improvements in functional recovery after stem cell therapy in the treatment of spinal cord injury in animal models was noticeable, but its outcome is strongly related to the site of injury, number of transplanted cells, and type of transplanted cells.
Subject(s)
Cell- and Tissue-Based Therapy , Contusions , Models, Animal , Spinal Cord Injuries , Spinal Cord , Stem Cell Transplantation , Stem CellsABSTRACT
Background: Septoplasty is one of the most commonly performed operations with several complications
Purpose: To categorize and demonstrate the probability of the occurrence of septoplasty complications
Methods: Three hundred and twelve patients who underwent septoplasty in Loghman Hakim general hospital, Tehran, Iran, were followed up for 6 months and evaluated for probable post-operative complications
Results: The most common complication was remained deviation, which was observed in 26.2% of patients followed by synechiae and perforations. There was no case of serious and life threatening complications
Conclusion: Septoplasty has both aesthetic and functional complication. However, meticulous and careful surgery can prevent most of them
ABSTRACT
Background: Rhinoplasty is one of the most common aesthetic procedures. It has several potential complications. There is no systematic study with direct focus on these complications
Purpose: To evaluate the likelihood for occurrence of different complications following septorhinoplasty
Methods: One hundred and fifteen patients who underwent rhinoplasty were observed for post-operative occurrence of nasal obstruction, hyponasal speech, post nasal discharge [PND], rhinorrhea, facial congestion and headache. They were also examined for aesthetic results of the surgery and asked about their satisfaction about the external shape of the nose as well as overall satisfaction of surgery
Results: Twenty-one patients developed sinonasal symptoms after surgery. The most annoying symptom was permanent unilateral nasal obstruction, which was observed in 38% of patients followed by long lasting PND [19%], anosmia [14%] and altered voice resonance [9%]. Five patients eventually underwent surgery due to their functional problems
Conclusion: Rhinoplasty and septorhinoplasty have numerous complications. Nasal obstruction, PND and anosmia are the most common. A careful follow-up is required for diagnosis and appropriate treatment of these complications
ABSTRACT
Background: The development of computed tomography [CT] technique results in development in visualization of the anatomic structures of the lateral nasal wall. It allows the anatomic variations of this region to be identified precisely, which is important in surgical treatment of chronic rhinosinusitis
Purpose: The aim of this study was to determine the incidence of anatomic variations of the lateral nasal wall in a group of patients with chronic rhinosinusitis and to compare these results with the control group
Methods: One hundred patients with chronic rhinosinusitis and 50 control subjects who were referred to Loghman Hakim general hospital, Tehran, Iran, were included in this retrospective study
Results: High septal deviation, presence of large bulla ethmoidalis and middle turbinate concha bullosa showed to be statistically correlated to increased risk of chronic rhinosinusitis .For other anatomical variations, no statistically significant differences in incidence of chronic rhinosinusitis observed
Conclusion: Relation between anatomical variation and rhinosinusitis was confirmed only for high septal deviation, middle turbinate concha bollusa and large bulla ethmoidalis. Surgical Approach to these variations may have a role in prevention or treatment of rhinosinusitis
ABSTRACT
Hemangiopericytoma is a malignant vascular tumor that is rarely seen in the nasal cavity and paranasal sinuses. Biological behavior of the tumor is not completely known and its natural history is not predictable. According to the existing literature, local recurrence rate is not common and distant metastasis is exceedingly rare and majority of patients have a favorable clinical course. We have presented female Persian case of sinonasal hemangiopericytoma in which recurrence of the tumor happened very rapidly after initial removal. It also recurred within two months after reoperation. We have discussed about the characteristics of these tumors and known prognostic factors. We have finally proposed that the sinonasal hemangiopericytoma may have significantly more aggressive clinical course than the previous assumption
ABSTRACT
Otosclerosis is a common cause of conductive hearing loss. It is surgically treated with stapedectomy or stapedotomy. Sensory-neural hearing loss is an uncommon but known complication of this surgery. A 25-year-old Iranian female with bilateral otosclerosis underwent right stapedotomy and developed bilateral sensorineural hearing loss a few days after the surgery, which recovered with appropriate treatment. The possible causes and their clinical courses are discussed in this study. Sensorineural hearing loss after stapedotomy has many different etiologies. Generally, the causes which are not directly related to the surgery should also be considered
ABSTRACT
Multiple sclerosis [MS] has numerous neurologic signs and symptoms, including hearing impairment. The reports concerning the type and severity of hearing loss in MS patients vary and little is known about an association of the disease characteristics with changes in hearing status. To find the otologic and neuro-otologic manifestations of MS with the use of routine hearing assessment tools. The presence of neuro-otologic signs and symptoms were studied in 30 patients diagnosed with MS. Patients underwent pure tone audiometry, speech audiometry and acoustic brain stem response [ABR] tests. The results were compared with 30 healthy age and sex matched controls. The most common finding was sensory-neural hearing loss followed by dizziness and nystagmus. The shape of the audiogram and severity of hearing loss was associated with both chronicity and disease activity. There were abnormal latencies in ABR waves which were more significant with high velocity stimulus. Hearing status deserves careful attention in MS patients. It may be used as a diagnostic means or an indicator for evaluating the characteristics of the underlying disease
Subject(s)
Humans , Male , Female , Hearing Loss, Sensorineural/diagnosis , Vertigo/diagnosis , Dizziness/etiology , Vestibular Function Tests , Nystagmus, Pathologic , Audiometry, Pure-Tone/methods , Cohort Studies , Case-Control StudiesABSTRACT
Hemangiopericytoma is a vascular tumor that is rarely seen in the nose and paranasal sinuses. Biological behavior of these tumors is not completely known, and their natural history is not predictable. This case report presents a patient with a sinonasal hemangiopericytoma. Diagnosis and management of these uncommon tumors is discussed